If you check naked-mole rats (also called sand puppy) on wikipedia , you'll find them really fascinating. Long living and cancer resistant, with incredibly low metabolic rates. [It is the only mammalian thermoconformer, almost entirely ectothermic (cold-blooded) in how it regulates body temperature].
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â– A 2003 study discovered their extraordinary resistance to pain.
A New study published in CELL REPORTS might have worked out why.
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➡️Thermal hyperalgesia (TH), this response is caused when heat or inflammation causes molecules to bind around a sensory neuron receptor called TrkA, starting a signalling cascade, telling the brain to feel a burning sensation, even at normal temperatures.
Study suggests the small change in these TrkA receptors differentiates a sand puppy from other animals.
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➡️When naked-mole rat's TrkA compared to similar molecules in mice, study revealed a 3-amino acid change in the naked mole-rat TrkA molecule that significantly reduces it’s sensitivity, requiring roughly 10× the amount of stimulation. "Even though naked mole rat's TrkA was almost identical to that of a mouse, it has a very significant effect on the animal's ability to feel pain" says Garry R.
Lewin (lead author).
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➡️It may even be that evolution has selected the path of TrkA to be less functional, but not to the extent of putting the animal in danger. 👉To this same end by adulthood a naked mole rat will lose around two-thirds of their pain receptors when compared to other mammals👈.
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➡️Why nature evolved naked mole rat this way (Although they are unlikely to encounter the capsaicin)🤔?
-They do work hard in the harsh desert climate( for food) & live underground, where close contact could make the TH reaction uncomfortably hot. Limiting this reaction allows the naked mole rats to waste less energy, making them feel more comfortable in these hot environments. 👉"They have the lowest metabolic rate of any mammal. Evolution has shut down everything that is not absolutely necessary - including extra nerve receptors," says Lewin.👈___________________
☢🤞Hope you enjoyed reading? If yes, let me know 👇 in the comments.

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