Many of these factors are related, and the systemic factors mostly affects wound healing by influencing the local factors.

 

Factors affecting wound healing can be categorized into 

 

1. Local factors (VON PIE)

- Local factors are those that directly influence the characteristics of the wound itself.

 

2. Systemic factors (GASIS DOMAIN)

- Systemic factors are the overall health or disease state of the individual that affect his or her ability to heal

 

Local factors (VON PIE)

1. Oxygenation
    Wound that has proper oxygen supply from the vessels and the     
    surrounding, heal properly in due time.
 

    Infection may slow the healing process, by direct effects, causing
    immune reaction and necrosis of surrounding tissue.
    
3. External/Foreign body

    Presence of foreign bodies (for example a wound not properly debrided)
    may be a source of infection and inflammation.

4.

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Venous Insufficiency

    In venous insufficiency, there is poor drainage of tissue, deoxygenated
    blood with a pile of metabolic waste pools around the vessels and tissues,
    worsening the condition of the tissues and slowing regeneration. 

5. PVD

    When arteries are pathologically narrowed, there is reduced flow of blood
    to the distal areas beyond the narrowing.

6. Peripheral Neuropathy
    If the patient looses ability to feel, he would not be able to shift pressure.
    Prolonged pressure on an area might worsen an uncomplicated injury.
    Blood vessels may also not function properly when they loose they nerve
    supply.

Mnemonic: VON PIE
  Venous insufficiency 
  Oxygenation
  Neuropathy
  Peripheral vascular diseases
  Infections
  External/Foreign bodies

 

1. Gender and Sex hormones
2.
Age

3. Stress

4. Ischemia

5. Smoking

6. Diseases: Diabetes, Keloids, Fibrosis, Hereditary healing disorders and collagen diseases, Jaundice, Uremia

7. Obesity

8.
Medications: Glucocorticoids, NSAIDS, Chemotherapy (Bevacizumab etc)

9. Alcoholism

10. Immunocompromised conditions: Cancer, Radiation therapy, AIDS

11. Nutrition

Mnemonic: GASIS DOMAIN