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Investopedia
Nike Stock Swoons As Apparel Giant Withdraws Full-Year Outlook Ahead Of CEO Change
~1.1 mins read
Nike (NKE) shares tumbled in extended trading Tuesday after the company withdrew its full-year outlook ahead of its transition to a new CEO later this month.
The athletic apparel giant reported net income of $1.1 billion for the fiscal first quarter of 2025, down 28% from the year-ago period but above analysts' expectations. However, Nike's revenue of $11.59 billion, which fell 10% year-over-year, slightly missed the analyst consensus from Visible Alpha.
The year-over-year declines were largely anticipated, and investors will be watching how Elliott Hill leads the company when he takes the reins as CEO in mid-October. Hill is returning to Nike after retiring in 2020. 
The company did not offer guidance for the full fiscal year on its earnings call, saying the decision was made to give Hill more time in the CEO role. The company also said it would push back its investor day originally scheduled for Nov. 19.
Nike still offered a forecast for the second quarter, which fell short of expectations. Nike said it anticipates its revenue will decline 8% to 10% year-over-year in the period, compared to estimates of a 6.7% drop.
“A comeback at this scale takes time, but we see early wins—from momentum in key sports to accelerating our pace of newness and innovation," CFO Matthew Friend said.
Shares of Nike plunged over 7% in extended trading Tuesday following the news.
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Healthwatch
Think Your Child Has ADHD? What Your Pediatrician Can Do
~3.7 mins read
Problems with attention and focus, impulsivity, and constant motion are possible symptoms of ADHD.
A green blackboard with the letters A D H D in chalk, with hand-drawn, squiggly arrows in multiple colors of chalk pointing outward in all directions from the letters.
ADHD, or attention deficit hyperactivity disorder, is the most common neurobehavioral disorder of childhood. It affects approximately 7% to 8% of all children and youth in the US. As the American Academy of Pediatrics (AAP) points out in their clinical practice guideline for ADHD, that's more than the mental health system can handle, which means that pediatricians need to step up and help out.
So, if your child is having problems with attention, focus, hyperactivity, impulsivity, or some combination of those, and is at least 4 years old, your first step should be an appointment with your child's primary care doctor.

What steps will your pediatrician take?

According to the AAP, here's what your doctor should do:
Take a history. Your doctor should ask you lots of questions about what is going on. Be ready to give details and examples.
Ask you to fill out a questionnaire about your child. Your doctor should also give you a questionnaire to give to your child's teacher or guidance counselor.
A diagnosis of ADHD is made only if a child has symptoms that are
  • present in more than one setting: For most children, that would be both home and school. If symptoms are only present in one setting, it's less likely to be ADHD and more likely to be related to that setting. For example, a child who only has problems at school may have a learning disability.
  • causing a problem in both of those settings: If a child is active and/or easily distracted, but is getting good grades, isn't causing problems in class, and has good relationships in school and at home, there is not a problem. It bears watching, but it could be just personality or temperament.
  • There are ADHD rating scales that have been studied and shown to be reliable, such as the Vanderbilt and the Conners assessments. These scales can be very helpful, not just in making diagnoses, but also in following the progress of a child over time.
    Screen your child for other problems. There are problems that can mimic ADHD, such as learning disabilities, depression, or even hearing problems. Additionally, children who have ADHD can also have learning disabilities, depression, or substance use. It's important to ask enough questions and get enough information to be sure.

    Discussing treatment options for ADHD

    If a diagnosis of ADHD is made, your pediatrician should discuss treatment options with you.
  • For 4- and 5-year-olds: The best place to begin is really with parent training on managing behavior, and getting support in the classroom. Medications should only be considered in this age group if those interventions don't help, and the child's symptoms are causing significant problems.
  • For 6- to 12-year-olds: Along with parent training and behavioral support, medications can be very helpful. Primary care providers can prescribe one of the FDA-approved medications for ADHD (stimulants, atomoxetine, guanfacine, or clonidine). In this age group, formal classroom support in the form of an Individualized Education Program (IEP) or a 504 plan should be in place.
  • For 12- to 18-year-olds: The same school programs and behavioral health support should be in place. Medications can be helpful, but teens should be part of that decision process; shared decision-making is an important part of caring for teens, and for getting them ready to take on their own care when they become adults.
  • Follow-up care for a child with ADHD

    Your pediatrician also should follow up with you and your child. Early on, there should be frequent visits while you figure out the diagnosis, as well as any other possible problems. And if medication is prescribed, frequent visits are needed initially as you figure out the best medication and dose and monitor for side effects.
    After that, the frequency of the visits will depend on how things are going, but appointments should be regular and scheduled, not just made to respond to a problem. ADHD can be a lifelong problem, bringing different challenges at different times, and it's important that you, your child, and your doctor meet regularly so that you can best meet those challenges.
    Because together, you can.
    Watch a video of Dr. Erica Lee discussing behavioral therapies to help children with ADHD.


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    Healthwatch
    Harvard Health Ad Watch: Got Side Effects? There's A Medicine For That
    ~4.9 mins read
    A shaky hand holding a glass & a second hand gripping wrist for support; two images of the glass show against peach background.
    It's an unfortunate reality: all medicines can cause side effects. While there are a few tried-and-true ways to deal with drug side effects, here's a less common option to consider: adding a second medication.
    That's the approach taken with valbenazine (Ingrezza), a drug approved for a condition called tardive dyskinesia that's caused by certain medicines, most of which are for mental health. Let's dive into what TD is, how this drug is advertised, and what else to consider if a medicine you take causes TD.

    What is tardive dyskinesia?

    Tardive dyskinesia (TD) is a condition marked by involuntary movements of the face or limbs, such as rapid eye blinking, grimacing, or pushing out the tongue. TD is caused by long-term use of certain drugs, many of which treat psychosis.
    TD may be irreversible. Early recognition is key to improvement and preventing symptoms from getting worse. If you take antipsychotic medicines or other drugs that can cause TD, tell your prescribing health care provider right away about any worrisome symptoms.

    A sidewalk sale, a cookout in the park, and a pitch

    One ad for Ingrezza starts with a young man working with customers at a sidewalk sale. Though his mental health is much better, he says, now he's suffering with TD, a condition "that can be caused by some mental health meds." A spotlight shines on his hands as he fumbles and drops an instant camera he's selling. He seems embarrassed and his customers look perplexed.
    Next we see a young woman at a cookout in a park. The mysterious spotlight is trained on her face as she blinks and grimaces involuntarily. Her voiceover explains that she feels like her involuntary movements are "always in the spotlight."
    Later these two happily interact with others, their movement problems much improved. A voiceover tells us Ingrezza is the #1 treatment for adults with TD. The dose — "always one pill, once a day" — can improve unwanted movements in seven out of 10 people. And people taking Ingrezza can stay on most mental health meds.
    That's the pitch. The downsides come next.

    What are the side effects of this drug to control a side effect?

    As required by the FDA, the ad lists common and serious side effects of Ingrezza, including
  • sleepiness (the most common side effect)
  • depression, suicidal thoughts, or actions
  • heart rhythm problems
  • allergic reactions, which can be life-threatening
  • fevers, stiff muscles, or problems thinking, which may be life threatening
  • abnormal movements.
  • That's right, one possible side effect is abnormal movements — a symptom this drug is supposed to treat!

    What the ad gets right

    The ad
  • appropriately highlights TD as a troubling yet treatable condition that can cause stress and embarrassment and affect a person's ability to function
  • emphasizes once-daily dosing, presumably because the recommended frequency of a competitor's drug for TD is twice daily
  • shares clinical studies that support effectiveness claims
  • covers many of the most common and serious side effects.
  • What else should you know?

    Unfortunately, the ad skims over — or entirely skips — some important details. Below are a few examples.

    Which medicines cause TD?

    We never learn which medicines can cause TD (especially when used long-term), which seems vital to know. Many, but not all, are used to help treat certain mental health disorders, such as schizophrenia or bipolar disorder. Here are some of the most common.
    Mental health medicines:
  • haloperidol (Haldol)
  • fluphenazine (Prolixin)
  • risperidone (Risperdal)
  • olanzapine (Zyprexa).
  • Other types of medicines:
  • metoclopramide (Reglan), which may be prescribed for nausea, hiccups, and a stomach problem called gastroparesis
  • prochlorperazine (Compazine, Compro), most often prescribed for severe nausea, migraine headaches, or vertigo.
  • Also, the ad never explains that TD may be irreversible regardless of treatment. Because improvement is most likely if caught early, it's important for people taking these medicines to check in with their health provider if they notice TD symptoms described above — especially if symptoms are growing worse.

    What about effectiveness and cost?

    Seven in 10 people reported that their symptoms improved, according to the ad. How much improvement? That wasn't shared. But here's what I found in a key study:
  • Among 202 study participants with TD, only 24% reported having minimal or no symptoms of TD after six weeks of treatment with Ingrezza.
  • Up to 67% of study subjects reported smaller improvements in symptoms.
  • What happens after six weeks? A few small follow-up studies suggest that some people who continue taking Ingrezza may improve further over time.
    And the cost? That's also never mentioned in the ad. It's about $8,700 a month. No details on the financial assistance program, or who qualifies for free treatment, are provided.

    Are there other ways to manage TD?

    Well, yes. But the ad doesn't mention those either. Three approaches to discuss with your healthcare provider are:
  • Avoid drugs known to cause TD when other options are available.
  • If you need to take these medicines, it's safest to use the lowest effective dose for the shortest time possible. For example, limiting metoclopramide to less than three months lowers risk for TD.
  • If you notice TD symptoms, ask about lowering the dose or stopping the offending drug right away. This may successfully reverse, or reduce, the symptoms.
  • If you have TD, you and your health care provider can consider several options:
  • whether other drug treatments for TD not mentioned in the ad, such as deutetrabenazine (Austedo) or tetrabenazine (Xenazine), might cost less or minimize bothersome side effects
  • botulinum toxin injections (Botox), which can relax the muscle contractions causing involuntary movements
  • deep brain stimulation, which involves electrical stimulation to certain areas of the brain to interrupt nerve signals to abnormally contracting muscles.
  • The bottom line

    The idea of treating a drug's side effect with another drug may not be appealing. Certainly, it makes sense to try other options first.
    But sometimes there are no better options. It's always worth asking whether a treatment is worse than the disease. But TD is one situation in which all options — including a drug treatment for another drug's side effects — are well worth considering.
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    Instablog9ja
    If Your Next Track Is Going To Sound Like Your Last One, Or The One Before That, Please Dont Release It, Rapper Dremo Advises His Colleagues
    ~0.2 mins read
    Rapper Dremo has advised his colleagues
    He said if your next track is going to sound like your last one, or the one before that, please don’t release it.
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