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Worldnews
Moldovas Pro-EU Party Wins Election Hit By Russian Interference Claims
~2.5 mins read
The governing party decisively victorious in parliamentary election widely viewed as a choice between Europe and Russia. By News Agencies Share Save Moldova’s pro-Western governing party has decisively won a parliamentary election plagued by claims of Russian interference and was widely seen as a definitive choice between staying in Europe’s orbit or lurching into Moscow’s. With nearly all polling station reports counted on Monday, electoral data showed the pro-European Union Party of Action and Solidarity (PAS) had 50.2 percent of the vote, while the pro-Russian Patriotic Electoral Bloc had 24.2 percent, according to The Associated Press news agency. The Russia-friendly Alternativa Bloc came third, followed by the populist Our Party. The pivotal ballot in the nation’s future on Sunday pitted the governing pro-European PAS against several Russia-friendly opponents. President of the European Commission, Ursula von der Leyen, welcomed the success of the pro-EU party. “Moldova, you’ve done it again. No attempt to sow fear or division could break your resolve. You made your choice clear: Europe. Democracy. Freedom. Our door is open. And we will stand with you every step of the way. The future is yours,” von der Leyen wrote on X. Ukrainian President Volodymyr Zelenskyy also welcomed the result and said Russia had “failed to destabilise Moldova”. “Even after spending huge, huge resources to undermine it and to corrupt whoever they could,” Zelenskyy added. Leading up to the vote, Moldovan Prime Minister Dorin Recean warned of Russian interference, saying Moscow is spending “hundreds of millions” of euros as part of an alleged “hybrid war” to try to seize power, which he described as “the final battle for our country’s future”. Russia had denied Moldova’s claims that it was waging a disinformation campaign and looking to buy votes and stir unrest. Geographically, Moldova is landlocked between Ukraine and EU member Romania. The country has, in recent years, moved westwards in attaining candidate status to the EU in 2022, just after Russia invaded Ukraine. Cristian Cantir, a Moldovan associate professor of international relations at Oakland University, told AP that PAS’s victory is “a clear win for pro-European forces in Moldova, which will be able to ensure continuity in the next few years in the pursuit of their ultimate goal of EU integration”. “A PAS majority saves the party from having to form a coalition that would have most likely been unstable and would have slowed down the pace of reforms to join the EU,” he said, adding, “Moldova will continue to be in a difficult geopolitical environment characterised by Russia’s attempts to pull it back into its sphere of influence.” The election day was marked by a string of incidents, ranging from bomb threats at multiple polling stations abroad to cyberattacks on electoral and government infrastructure, voters photographing their ballots, and some being illegally transported to polling stations. Three people were also arrested, suspected of plotting to cause unrest after the vote. On Friday, President Maia Sandu called the vote the country’s “most consequential election”. “Its outcome will decide whether we consolidate our democracy and join the EU, or whether Russia drags us back into a grey zone, making us a regional risk,” Sandu wrote on X. Recean, in the meantime, had also stressed the threat from Russia: “I call on every Moldovan at home and across Europe: We cannot change what Russia does, but we can change what we do as a people,” he said. “Turn worry into mobilisation and thoughtful action … Help stop their schemes.” Follow Al Jazeera English:...
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Healthwatch
What Is A PSA Test And How Is It Used?
~4.5 mins read
While PSA screening is controversial, experts advise men to discuss the test with their health provider. Who should be tested, and what do the results mean?
Gloved hand holding a vial of blood with the label PSA test; a rack of other tubes is out of focus below the hand.
Editor's note: first of two parts; read part two here.
In this two-part series, we’ll describe the PSA test — how it’s used, and how doctors perform next steps in the event of an abnormal reading. Our first post addresses PSA screening for prostate cancer. In the second part of our series, we’ll describe how doctors use the PSA test to check the status of a cancer that’s being watched or treated.

PSA testing: Screening for prostate cancer

All prostate cells make PSA, a protein that helps to dissolve semen so that sperm cells can more easily reach and fertilize an egg. Normal and cancerous cells in the prostate each make PSA in similar amounts. But since cancer cells are leakier, they release more of the protein into the bloodstream.
PSA screening for prostate cancer came into widespread use during the early 1990s. But the test is controversial: prostate cancer grows slowly, and the concern is that PSA screening flags too many low-grade tumors that might not be harmful during a man’s life. Still, studies do suggest that PSA testing, because it can detect cancers at early and more treatable stages, can be lifesaving in some cases.
The US Preventive Services Task Force (USPSTF), an influential volunteer panel of experts in prevention and evidence-based medicine, takes a cautious stance on the matter. The USPSTF advises doctors to discuss the pros and cons of PSA screening in men ages 55 to 69, but also cautions against screening men over the age of 70, and gives no recommendation at all for men under 55.
Some expert groups recommend earlier screening for men in higher-risk groups. Black men, for instance, are about twice as likely to be diagnosed with and die from prostate cancer than white men. The American Cancer Society (ACS) advises PSA screening for Black men at age 45, or even earlier screening for men with first-degree relatives who developed prostate cancer at young ages, as well as for men who test positive for mutations in certain cancer risk genes, such as BRCA1 and BRCA2.
Importantly, activities that put pressure on the prostate gland (such as biking and sex) can cause PSA levels in blood to spike, so you should refrain from these activities for two to three days prior to testing. Health conditions affecting the prostate, such as infections, inflammation (prostatitis), or enlargement of the gland that occurs normally in older men (benign prostatic hyperplasia), can also cause PSA levels to spike in ways that are unrelated to cancer.

What is an abnormal PSA result?

In general, PSA levels over 4 nanograms per milliliter (ng/mL) in blood are considered abnormal. But doctors may also vary PSA cutoffs by age. For instance, a PSA of 3.5 ng/mL for a man in his 40s “is definitely abnormal,” says Dr. Marc B. Garnick, the Gorman Brothers Professor of Medicine at Harvard Medical School and Beth Israel Deaconess Medical Center, and editor in chief of the Harvard Medical School Guide to Prostate Diseases. However, a PSA of 5.5 ng/mL among men in their 60s, Dr. Garnick adds, may not be. It’s best to think of PSA values as being on a continuum, with higher levels associated with having prostate cancer.
PSA testing can sometimes miss a cancer diagnosis altogether. One study found that up to 15% of men with PSA levels under 4 ng/mL actually did have prostate cancer, and a sizeable fraction of these tumors were clinically significant. It’s also possible for high-grade cancer to be present without causing a large increase in PSA. That’s because high-grade cancer cells can lose their ability to actually make the protein.

What are next steps after an abnormal result?

It used to be that elevated PSA readings were followed routinely by a prostate biopsy, and then treatment if cancer was detected.
Today the paradigm is shifting. An abnormal result is now likely to be followed by a magnetic resonance imaging (MRI) scan, which can identify areas of the prostate gland that look suspicious for cancer. In Europe and some hospitals in the US, men with abnormal PSA readings might avoid an initial biopsy altogether if the MRI results are negative. However, many physicians will still opt for an initial biopsy in such cases, followed by periodic PSA tests and MRI scans to determine if further biopsies are needed.
If the initial biopsy and MRI results are positive, then doctors will perform a targeted biopsy focused on areas where the MRI showed evidence of cancer. If a cancer diagnosis is confirmed, then next steps will be initiated. Today, many low-grade cancers are watched with active surveillance, and treated only if follow-up biopsies and MRI scans show worsening of the disease. Higher-grade cancers will be treated immediately.
"The goal of this risk-adapted approach to screening," Dr. Garnick says, is to “identify clinically significant cancers that actually do need treatment while decreasing diagnoses of clinically insignificant cancers that do not.”

Variations on the PSA test

Rather than subject everyone with an elevated PSA reading to a biopsy, some doctors perform additional tests that involve more detailed interpretations of PSA levels.
  • Free PSA testing looks for PSA that isn’t bound to other proteins. Low percentages of free PSA are associated with higher cancer risk.
  • PSA density divides the total PSA level in ng/mL by the volume of the prostate gland in milliliters. A PSA density of 0.15 ng/mL or higher may be associated with prostate cancer.
  • PSA velocity tracks how fast PSA levels increase from test to test.
  • Prostate Health Index combines total PSA, free PSA, and a type of PSA called proPSA. Some evidence suggests it diagnoses prostate cancer more accurately than PSA by itself.
  • In the next part of our series, we’ll address how PSA is used as a test for monitoring and managing patients with prostate cancer.

    dataDp/1032.jpeg
    Worldnews
    Malaysias Mahathir At 100: Israels Genocide In Gaza Will Not Be Forgotten
    ~5.5 mins read
    Former Malaysian Prime Minister Mahathir Mohamad says Israel ‘did not learn anything’ from its experience of genocide by Nazi Germany. By Amy Chew Share Save Putrajaya, Malaysia – When Malaysia’s former Prime Minister Mahathir Mohamad turned 100 earlier this year, he marked his birthday by following a lifelong routine of discipline: he ate little, worked a lot, and did not succumb to the lure of rest. “The main thing is that I work all the time. I don’t rest myself,” Mahathir told Al Jazeera. “I am always using my mind and body. Keep your mind and body active, then you live longer,” he said. From a desk at his office in Putrajaya city, south of the capital, Kuala Lumpur, he spent his centenary like most days: penning his thoughts on the Malaysian economy, the country’s political situation and unfolding world events, particularly the situation in Gaza. Sitting down with Al Jazeera for an interview after recovering from a spell of exhaustion around the time of his birthday, Mahathir predicted that Israel’s ruthlessness against the Palestinian population of Gaza would be etched into world history. Israel’s killing of nearly 66,000 Palestinians in Gaza, the majority women and children, will be remembered for generations, possibly for “centuries”, Mahathir said. “Gaza is terrible. They killed pregnant mothers… babies just born, young people, boys and girls, men and women, the sick and the poor… How can this be forgotten?” he asked. “It will not be forgotten for maybe centuries,” Mahathir said. Describing the war in Gaza as a genocide that parallelled the killing of Muslims during the war in Bosnia in the early 1990s and the Jews by Nazi Germany during World War II, Mahathir said he was confounded that the people of Israel, who had experienced genocide, could, in turn, perpetrate a genocide. “I thought people who suffered like that would not want to visit it on other people,” he said. Victims of a genocide should “not want to wish their fate to befall other people”. However, in the case of Israel, he was wrong, he said. At the height of his power in the 1980s and 1990s, Mahathir earned a reputation on the world stage as an outspoken voice for the Global South, and a vocal critic of Western imperialism and its contemporary exploitation of developing countries through flows of financial capital. A staunch and lifelong supporter of the Palestinian cause, Mahathir was also roundly criticised for making “anti-Semitic” statements alongside his tirades against the West, particularly the United States. But, as he told Al Jazeera, he had sympathised deeply with the Jewish people when the horrors of the Nazis became known after World War II. Israelis, he now says, “did not learn anything from their experience”. “They want the same thing that happened to them, they want to do it to the Arabs,” he said. Now, the only “reasonable” way to address the conflict between Israel and the Palestinian people is to implement a two-state solution, he added. But Mahathir said that such a solution – which received a major boost when Palestinian statehood was recently recognised by Australia, Belgium, Canada, France and the United Kingdom, among other countries – is still a very long way off, and he would not live to see it. “In my lifetime, no. Too short a time,” he said. A survivor of three heart attacks who pulled off a stunning political comeback in Malaysian public life when he was over 90 years of age, Mahathir held power for a combined total of 24 years, and earned himself what is likely to be the unassailable title as Malaysia’s longest-serving leader. When he was born on July 10, 1925, in the northern Malaysian state of Kedah, the king of England was George V, the grandfather of the late Queen Elizabeth II, and Malaysia was a British colony known as Malaya. He entered politics in the 1960s and became prime minister from 1981 to 2003 before stepping down, for the first time. He then made an astonishing return to power in 2018, when he led a coalition of opposition parties to beat the long-governing Barisan Nasional party to be re-elected prime minister at the sprightly age of 92, becoming the world’s oldest leader as a result. But he stepped down under a cloud for the last time in 2020 after losing support due to political machinations from inside his own political party, Bersatu. A medical doctor by training, even Mahathir’s critics acknowledged that he laid the economic foundations that transformed Malaysia’s agricultural economy of the 1960s into the modern industrialised state of today, with the iconic twin Petronas Towers crowning the skyline of its thriving modern capital city, Kuala Lumpur. Despite having lived past the age when most politicians would have retreated from the spotlight, Mahathir at 100 remains as vocal, sharp and acerbic as ever. He also had some surprising memories of a bygone China and predictions about the future of the United States to share. Among his prized recollections are his impressions of visiting China in the 1970s, when it was “very poor” and there were few cars on the streets. Being Malaysia’s deputy prime minister at the time, authorities in Beijing rolled out the red carpet and their “Red Flag” model car to chauffeur him around, he said. “It was a very big Chinese car which China produced themselves. They called it The Red Flag,” Mahathir said, recounting how that vehicle was among the first to be independently produced by the Chinese. Fast forward to today, China’s economy has come a very long way, and so too has its thriving car industry, which is giving Western-produced cars a run for their money, particularly with electric vehicles. China’s surpassing of the US to become the “number one country in the world” is inevitable, he said, due to its huge domestic market and hard-working population. “It will take China 10 years to catch up with America. After that, China will overtake America,” Mahathir said. “China by itself is bigger than Europe and America. It’s a huge market. It is quite rich. And Chinese people are very smart in business,” he said, recounting how, as a youth, he witnessed new Chinese migrants to Malaysia take on “very heavy work” to earn a living. Within a generation or two, those families had managed to improve their lives, give their children a good education, and some of their grandchildren had gone on to become quite wealthy. Contrasting contemporary China with the US under the presidency of Donald Trump, Mahathir said that Trump’s “tariff war” was “very damaging”, and his plans to bring production back to the US would increase costs and pave the way for China’s further rise. “[Trump] wants companies to shift their factories to America. The wages are very high there. The work attitude there will be very different from Chinese workers, who can stay for hours and do the work,” he said. “American workers cannot do that. Anything produced in America in the future, if they do move the factories there, will be costly,” he added. “America will not be able to compete with the rest of the world.” Importantly, Trump does not have the time to follow through on his promised economic vision, as it would take a minimum of three to eight years to move manufacturing facilities to the US, he said. “And Trump will not be president any more after three years,” he added. Despite being 100 years old , Mahathir walks unaided, exercises daily, goes to work every day and receives visitors. He uses social media and travels outside of Malaysia whenever he receives invitations to be a guest speaker. The key to longevity, Mahathir said, is to stay physically and mentally active and not overeat . “Don’t eat so much,” he told Al Jazeera. “My mother’s best advice to me was, ‘When the food tastes nice, stop eating.'” Follow Al Jazeera English:...
    Read this story on Aljazeera
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    Healthwatch
    What Is A PSA Test And How Is It Used?
    ~4.5 mins read
    While PSA screening is controversial, experts advise men to discuss the test with their health provider. Who should be tested, and what do the results mean?
    Gloved hand holding a vial of blood with the label PSA test; a rack of other tubes is out of focus below the hand.
    Editor's note: first of two parts; read part two here.
    In this two-part series, we’ll describe the PSA test — how it’s used, and how doctors perform next steps in the event of an abnormal reading. Our first post addresses PSA screening for prostate cancer. In the second part of our series, we’ll describe how doctors use the PSA test to check the status of a cancer that’s being watched or treated.

    PSA testing: Screening for prostate cancer

    All prostate cells make PSA, a protein that helps to dissolve semen so that sperm cells can more easily reach and fertilize an egg. Normal and cancerous cells in the prostate each make PSA in similar amounts. But since cancer cells are leakier, they release more of the protein into the bloodstream.
    PSA screening for prostate cancer came into widespread use during the early 1990s. But the test is controversial: prostate cancer grows slowly, and the concern is that PSA screening flags too many low-grade tumors that might not be harmful during a man’s life. Still, studies do suggest that PSA testing, because it can detect cancers at early and more treatable stages, can be lifesaving in some cases.
    The US Preventive Services Task Force (USPSTF), an influential volunteer panel of experts in prevention and evidence-based medicine, takes a cautious stance on the matter. The USPSTF advises doctors to discuss the pros and cons of PSA screening in men ages 55 to 69, but also cautions against screening men over the age of 70, and gives no recommendation at all for men under 55.
    Some expert groups recommend earlier screening for men in higher-risk groups. Black men, for instance, are about twice as likely to be diagnosed with and die from prostate cancer than white men. The American Cancer Society (ACS) advises PSA screening for Black men at age 45, or even earlier screening for men with first-degree relatives who developed prostate cancer at young ages, as well as for men who test positive for mutations in certain cancer risk genes, such as BRCA1 and BRCA2.
    Importantly, activities that put pressure on the prostate gland (such as biking and sex) can cause PSA levels in blood to spike, so you should refrain from these activities for two to three days prior to testing. Health conditions affecting the prostate, such as infections, inflammation (prostatitis), or enlargement of the gland that occurs normally in older men (benign prostatic hyperplasia), can also cause PSA levels to spike in ways that are unrelated to cancer.

    What is an abnormal PSA result?

    In general, PSA levels over 4 nanograms per milliliter (ng/mL) in blood are considered abnormal. But doctors may also vary PSA cutoffs by age. For instance, a PSA of 3.5 ng/mL for a man in his 40s “is definitely abnormal,” says Dr. Marc B. Garnick, the Gorman Brothers Professor of Medicine at Harvard Medical School and Beth Israel Deaconess Medical Center, and editor in chief of the Harvard Medical School Guide to Prostate Diseases. However, a PSA of 5.5 ng/mL among men in their 60s, Dr. Garnick adds, may not be. It’s best to think of PSA values as being on a continuum, with higher levels associated with having prostate cancer.
    PSA testing can sometimes miss a cancer diagnosis altogether. One study found that up to 15% of men with PSA levels under 4 ng/mL actually did have prostate cancer, and a sizeable fraction of these tumors were clinically significant. It’s also possible for high-grade cancer to be present without causing a large increase in PSA. That’s because high-grade cancer cells can lose their ability to actually make the protein.

    What are next steps after an abnormal result?

    It used to be that elevated PSA readings were followed routinely by a prostate biopsy, and then treatment if cancer was detected.
    Today the paradigm is shifting. An abnormal result is now likely to be followed by a magnetic resonance imaging (MRI) scan, which can identify areas of the prostate gland that look suspicious for cancer. In Europe and some hospitals in the US, men with abnormal PSA readings might avoid an initial biopsy altogether if the MRI results are negative. However, many physicians will still opt for an initial biopsy in such cases, followed by periodic PSA tests and MRI scans to determine if further biopsies are needed.
    If the initial biopsy and MRI results are positive, then doctors will perform a targeted biopsy focused on areas where the MRI showed evidence of cancer. If a cancer diagnosis is confirmed, then next steps will be initiated. Today, many low-grade cancers are watched with active surveillance, and treated only if follow-up biopsies and MRI scans show worsening of the disease. Higher-grade cancers will be treated immediately.
    "The goal of this risk-adapted approach to screening," Dr. Garnick says, is to “identify clinically significant cancers that actually do need treatment while decreasing diagnoses of clinically insignificant cancers that do not.”

    Variations on the PSA test

    Rather than subject everyone with an elevated PSA reading to a biopsy, some doctors perform additional tests that involve more detailed interpretations of PSA levels.
  • Free PSA testing looks for PSA that isn’t bound to other proteins. Low percentages of free PSA are associated with higher cancer risk.
  • PSA density divides the total PSA level in ng/mL by the volume of the prostate gland in milliliters. A PSA density of 0.15 ng/mL or higher may be associated with prostate cancer.
  • PSA velocity tracks how fast PSA levels increase from test to test.
  • Prostate Health Index combines total PSA, free PSA, and a type of PSA called proPSA. Some evidence suggests it diagnoses prostate cancer more accurately than PSA by itself.
  • In the next part of our series, we’ll address how PSA is used as a test for monitoring and managing patients with prostate cancer.

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