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Artificial Intelligence Predicts Survival In Epithelial Ovarian Cancer
~1.1 mins read

Radiomic Prognostic Vector IDs patients with median overall survival of less than two years

FRIDAY, Feb. 15, 2019 (HealthDay News) — Artificial intelligence software can predict prognosis in epithelial ovarian cancer (EOC) above established prognostic methods, according to a study published online Feb. 15 in Nature Communications.
Haonan Lu, from the Ovarian Cancer Action Research Centre at Imperial College London, and colleagues extracted 657 quantitative mathematical descriptors from the preoperative computed tomography images of 364 EOC patients at their initial presentation. A noninvasive summary statistic of the primary ovarian tumor was derived using machine learning, based on four descriptors, and named Radiomic Prognostic Vector (RPV).
The researchers found that RPV was able to reliably identify the 5 percent of patients with median overall survival of less than two years, significantly improving established prognostic methods. RPV was validated in two independent multicenter cohorts. Stromal phenotype and DNA damage response pathways were activated in RPV-stratified tumors as elucidated by genetic, transcriptomic, and proteomic analysis from two independent datasets.
“The long-term survival rates for patients with advanced ovarian cancer are poor despite the advancements made in cancer treatments. There is an urgent need to find new ways to treat the disease,” a coauthor said in a statement. “Our technology is able to give clinicians more detailed and accurate information on the how patients are likely to respond to different treatments, which could enable them to make better and more targeted treatment decisions.”

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Sun-Care Products That Dermatologists Use
~5.2 mins read
When the sun comes out, it’s only natural to reach for the SPF. Of course, protecting your skin from the sun shouldn’t be just a summertime habit. After all, harmful ultraviolet rays — the ones responsible for skin cancer, sunburns, and premature aging — don’t go away just because it’s cold or cloudy outside, the American Academy of Dermatology notes.
“UV rays can harm our skin during any season and any type of weather,” says Sourab Choudhury, DO, a board-certified dermatologist and the chief medical officer at Dermatology Specialists in New York City. “The temperature outside doesn’t matter from a UV perspective. The sun’s rays can shine just as powerfully on a cold day as they might during the summer.”
Dr. Choudhury says that even short and intense exposure to sun, such on a walk down the street or during a car ride on a sunny day, can cause sun damage. “Apply sunscreen generously and apply it often, even when it’s cloudy,” he says. And if possible, give yourself at least half an hour after applying your sunscreen before you leave your home — this will help give your sunscreen time to “bind” to your skin before you’re exposed to the sun, per the Skin Cancer Foundation.
Sure, it adds an extra step to your day, but it’s worth it. Studies show that sunscreen can help protect against three common skin cancers — squamous cell carcinomabasal cell carcinoma, and melanoma — according to Harvard Health Publishing. The American Cancer Society notes that if you protect your skin from UV radiation, you can help prevent most skin cancers diagnosed in the United States (which number over five million annually). Plus, shielding your skin from the sun can help slow the signs of aging, according to the American Academy of Dermatology.
Your arsenal of sun-protection products isn’t limited to traditional sunscreens, though. Today, the market is filled with other types of skin-care products with built-in SPF, sunscreens that are lighter and less greasy than those of yesteryear, and clothing with sun protection woven into the fabric.
Here are 10 sun-care products that the pros recommend.

1. EltaMD UV Elements Broad-Spectrum SPF 44

Kathleen Suozzi, MD, the director of aesthetic dermatology at Yale Medicine in New Haven, Connecticut, loves this sunscreen from EltaMD for its hydrating properties: “It’s formulated with hyaluronic acid, so it is very hydrating and leaves a dewy finish to the skin,” she says. This mineral sunscreen offers sun protection thanks to zinc oxide and titanium dioxide, two ingredients which help shield you from harmful UV rays by deflecting them away from the skin (per an article in Consumer Reports).

2. Coolibar UPF Clothing

Clothes with an ultraviolet protection factor (UPF) provide full coverage against the sun and can be especially useful for those who have trouble remembering to reapply sunscreen, as well as those who tend to miss a spot when applying. It’s true that all clothing protects your skin from the sun to a certain degree, but UPF clothing takes it a step further, says Todd Minars, MD, a board-certified dermatologist and the founder of Minars Dermatology in Hollywood, Florida. “UPF clothing works by being very tightly woven together so that the sun's UV rays can't penetrate to reach the skin,” he says.

3. C’est Moi Gentle Mineral Sunscreen Lotion Broad Spectrum SPF 30

Nava Greenfield, MD, a dermatologist with Schweiger Dermatology Group in New York City, says that this C’est Moi sunscreen is perfect for her sensitive skin. “It is very protective with only mineral blockers and won’t cause breakouts,” she says. “I love the travel size, which is small enough for me to bring in my bag wherever I go so I can reapply.”

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