Norco works by binding to specific receptors in the brain and spinal cord called opioid receptors. Hydrocodone, the opioid component of Norco, binds to these receptors and blocks pain signals from reaching the brain, which can reduce the perception of pain. Acetaminophen, the other component of Norco, works by inhibiting the production of prostaglandins, which are chemicals in the body that contribute to pain and inflammation. By blocking the production of prostaglandins, acetaminophen can also help to reduce pain and fever. When taken together, the hydrocodone and acetaminophen in Norco can provide more effective pain relief than either drug taken alone. However, it’s important to note that Norco can have side effects and risks, so it should only be taken as directed by a healthcare professional.