The prevention and control of locally endemic and epidemic disease is an important aspect of primary health care.health for all cannot be achieved.unlesd positive effort are made to control the major communicable and non communicable disease that plague many developing countries, using appropriate and affordable ways some of the major endemic.disease are covered.and include.malaria infection, viral disease ( yellow fever) bacteria disease (cholesterol m) helminth infestation (leprosy, typhoid fever, tubercle) and loasis as well as sexually disease, including AIDS. Some of these disease often occurred.as serious epidemic killing many people.e.g yellow fever,Lassa fever,cholera.outbreak of these.disease have increased.wordwide and in recent.year.many developing countries have faced serious epidemic of these disease.Reason for this includes faster travel and greater distance covered, urbanization, overcrowding,poor nutrition and lack of safe water and sanitation.

Malaria is cause by infection with sporozoa of the genus plasmodium, transmitted in nature by the bite of female mosquito.four species of plasmodium are responsible for many infection.